Human bronchial fibroblasts express the 5-lipoxygenase pathway

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Human bronchial fibroblasts express the 5-lipoxygenase pathway

BACKGROUND Fibroblasts are implicated in sub-epithelial fibrosis in remodeled asthmatic airways and contribute to airway inflammation by releasing cytokines and other mediators. Fibroblast activity is influenced by members of the leukotriene family of bronchoconstrictor and inflammatory mediators, but it is not known whether human bronchial fibroblasts can synthesize leukotrienes. METHODS The...

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O04 - Effects of 5-lipoxygenase pathway inhibition on rhinovirus-associated bronchial epithelial inflammation

Background Human bronchial epithelial cells produce a variety of inflammatory mediators upon exposure to rhinovirus (RV), a major precipitant of asthma exacerbations. We hypothesized that anti-leukotriene (LT) treatment of epithelial cells with or without exposure to supernatants of RV-infected peripheral blood mononuclear cells (PBMCs) may inhibit RV-induced up-regulation of inflammatory cytok...

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Association of 5-lipoxygenase gene polymorphisms with bronchial asthma

Leukotrienes are important pro-inflammatory mediators in bronchial asthma (BA) and are derived from arachidonic acid by the action of 5-lipoxygenase (5-LO). We investigated the association of 5-LO gene polymorphisms with BA. Thirty-six single-nucleotide polymorphisms (SNPs) of the 5-LO gene, as referenced in the dbSNP gene bank, were analyzed with sequencing and allele-specific PCR (AS-PCR) in ...

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The yin and the yang of 5-lipoxygenase pathway activation.

The 5-lipoxygenase pathway is the source of potent proinflammatory mediators. More than 20 years ago, the details of the 5-lipoxygenase pathway began to emerge from seminal work performed by Borgeat and Murphy while they were working in the laboratory of Bengt Samuelsson (Borgeat and Samuelsson, 1979; Murphy et al., 1979). A vast body of evidence has subsequently accrued regarding the cells of ...

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ژورنال

عنوان ژورنال: Respiratory Research

سال: 2006

ISSN: 1465-993X

DOI: 10.1186/1465-9921-7-102